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Irbesartan stops angiotensin II binding towards the AT1 receptor in tissues like vascular smooth muscle mass along with the adrenal gland. Irbesartan and its active metabolite bind the AT1 receptor with 8500 instances far more affinity than they bind for the AT2 receptor.
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If digitalis has also been administered, hypokalemia could accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is taken out by hemodialysis has not been established. The oral LD50 of hydrochlorothiazide is larger than ten g/kg in each mice and rats.
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Blockade from the AT1 receptor gets rid of the damaging opinions of angiotensin II on renin secretion, but the resulting enhanced plasma renin exercise and circulating angiotensin II don't defeat the effects of irbesartan on blood pressure.
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